RIULS

Repository of Iasi University of Life Sciences, ROMANIA

Welcome to RIULS!

The mission of the University’s institutional repository is to manage, preserve and disseminate, in open access, the academic and institutional output of the university’s academic community. It also aims to promote values and personalities belonging to Romanian agricultural science, by storing digitized versions of rare books and manuscripts from its collections.

The repository is part of the international movement known as open science, which promotes free access to scientific literature. This translates into maximized impact of the work carried out by researchers, contribution to improving access to knowledge, increased visibility of the institution through the works of its authors and improvement of its search engine ranking.

All documents deposited in the repository receive a unique and persistent identifier called a Handle, thus guaranteeing perpetual access to scientific output through permanent links.

RIULS Repository of Iași University of Life Sciences is indexed in Duraspace, OpenDOAR,CORE,Google Scholar,BASE (Bielefeld Academic Search Engine) and ROAR (Registry of Open Access Repositories), global Directories of Open Access Repositories.

Categories in RIULS

Select a category to browse its collections.

Now showing 1 - 3 of 3

Colecții speciale - Ad Gloria Agris / Special Collections-Ad Gloria Agris 141
Cuprinde cărți și publicații periodice rare ale fondatorilor agriculturii și ai învățământului agricol românesc modern, precum și teze de doctorat din domeniul agricol de la început de secol XX.
Publicații ale Bibliotecii - Librum de libris / Publications of the Library - Librum de libris 13
Contains publications created by the Library’s staff: bibliographies, articles, tutorials, etc.
Publicații științifice ale Universității – AgriScriptum / Scientific Publications of the University - AgriScriptum 6501
Contains documents resulting from scientific research produced or edited by the departments, research institutes and study centres of the University: Doctoral Theses, articles published in ISI journals, articles published in the journals edited by the University, patents, scientific projects, etc.

Recent Submissions

listelement.badge.access-status Open Access ,
The Role of Spacer Segments in Increasing the Transfection Efficacy of Au-Core Polymeric-Shell Nanoparticulate Gene Vectors
(American Chemical Society, 2026-01-14) Bostiog, Denisse I.; Năstasă, Valentin; Cristina M. Al-Matarneh; Peptanariu, Dragoș; Mareș, Mihai; Pașca, Sorin-Aurelian; Bostănaru-Iliescu, Andra-Cristina; Crăciun, Bogdan F.; Vasiliu, Tudor; Puf, Răzvan; Maier, Stelian S.; Pinteală, Mariana
The surface chemistry of gold nanoparticles is a key determinant of their final biological properties. In this study, we investigated the influence of the PEG chain length, positioned between the gold core and the cationic polymer, on the transfection efficiency in HeLa and HGF cell lines. Two types of nonviral vectors were synthesized from the same AuNPs, which were subsequently functionalized with PEG of 1000 and 2500 Da, respectively. Onto these PEG chains, identical copolymeric sequences of PEI2000-PEG500-GA were covalently attached to provide quasi-shielding (via PEG500) and enable tumor targeting/accumulation (via GA). Both vectors demonstrated that such functionalization enhances cellular uptake and targeting specificity while exhibiting excellent DNA delivery efficiency, minimal in vitro cytotoxicity, and no detectable in vivo adverse effects following intravenous administration in animal models. A superior loading capacity was observed when the PEG linked to the gold core was 2500 Da, suggesting a contribution from solvation-driven interactions.
listelement.badge.access-status Open Access ,
Co-encapsulated fluorescent magnetic nanoparticles for potential applications in breast cancer therapy: Exploratory in vitro and in vivo studies
(Elsevier, 2026-04-26) Sandu, Ștefan; Dodi, Gianina; Gardikiotis, Ioannis; Crețu, Bianca-Elena-Beatrice; Luca, Andreea; Cojocaru, Florina Daniela; Vereștiuc, Liliana; Pașca, Sorin-Aurelian; Balan, Vera
This study describes, for the first time in the literature, a suitable approach to develop co-encapsulated magnetic nanoparticles based on fluorescent biotinylated N-palmitoyl chitosan, hydrophobic magnetite, Docetaxel and Verapamil. The multicomponent nanostructures were obtained using a two-step method: ultrasonication-induced self-assembly followed by ionic gelation. Structural composition was confirmed by infrared spectroscopy; the magnetic nanostructures displayed an average hydrodynamic diameter of 322.20 ± 2.50 nm, a positive surface charge (5.63 ± 0.16 mV), good magnetic saturation (13.35 emu/g) and superparamagnetic behavior. In vitro drug release studies revealed a pH-responsive behavior for both encapsulated agents, with an enhanced release of the Verapamil. Cytotoxicity evaluation using live/dead assays on MCF-7 tumor spheroids embedded in collagen-based hydrogels demonstrated a substantial therapeutic effect. Serum interleukin-8 (IL-8) levels were quantified to evaluate systemic inflammatory responses following intravenous administration of drug free magnetic nanoparticles. IL-8 concentrations were considerably increased at day 3, indicating an acute inflammatory response, decreased during the subacute phase (days 7 and 14) and returned to control levels by day 21, demonstrating good biocompatibility. No significant toxicity was observed for magnetic nanoparticles in the rats. Overall, these findings suggest that the developed magnetic nanoplatforms represents a promising candidate for breast cancer applications and merits further in vivo investigation to elucidate the action mechanism of encapsulated therapeutics and their pharmacologic activity.
listelement.badge.access-status Open Access ,
MRI-Based Radiomics Reveals Cannabinoid-Associated Tumor Phenotypes in a Murine Breast Cancer Model
(MDPI, 2026-03-31) Creangă-Murariu, Ioana; Pricope, Cosmin-Vasilică; Ciorpac, Mitică; Anaby, Debbie; Cohen, Kfir; Urîtu, Cristina-Mariana; Szilagyi, Andrei; Gogu, Raluca-Maria; Jalloul, Wael; Aniță, Adriana-Elena; Anită, Dragoș-Constantin; Baisan, Radu-Andrei; Alexa-Stratulat, Teodora; Tamba, Bogdan-Ionel
Introduction and Aim: Assessment of antitumor activity in preclinical models remains challenging when relying solely on conventional size-based imaging, particularly for complex agents such as cannabinoids, whose biological effects may not translate into early volumetric tumor changes. Cannabinoid formulations, including the synthetic cannabinoid JWH-182, Cannabixir® Medium dried flowers, and Cannabixir® THC full extract, exhibit diverse and potentially subtle effects on tumor biology. Radiomics enables high-throughput extraction of quantitative imaging features that capture intratumoral heterogeneity beyond gross tumor volume. The primary aim of this study was to evaluate the utility of MRI-based radiomics as a sensitive tool for detecting cannabinoid-associated tumor phenotypic modulation in a preclinical breast cancer model. Methods: Orthotopic breast tumors were induced in mice using the 4T1 cell line. Animals received cannabinoid formulations in combination with chemotherapy according to a predefined protocol. Tumor burden was assessed at baseline and post-treatment using ultrasonography and whole-body MRI to calculate tumor doubling time. T1- and T2-weighted MRI datasets were segmented and analyzed using radiomics to extract morphometric and signal-based features. Results: Conventional imaging revealed no significant differences in tumor doubling time between most cannabinoid-treated groups and controls, except for accelerated growth in animals treated with Cannabixir® THC full extract. In contrast, radiomics identified distinct, compound-specific tumor phenotypes, including structural features consistent with reduced aggressiveness, in JWH-182-treated tumors, despite similar volumetric growth patterns. Conclusion: MRI-based radiomics sensitively captures cannabinoid-associated tumor phenotype alterations beyond volumetric assessment, supporting its value as a pharmaco-imaging tool for characterizing treatment-related tumor biology in preclinical oncology.
listelement.badge.access-status Open Access ,
Comparative Anatomy of the Hyoid Apparatus in Various Dog Breeds: Insights From Clinical Imaging
(Wiley, 2026-04-10) Altundağ, Yusuf; Ozkan, Ermiş; Yiğit, Funda; Avanus, Kozet; Hadziomerovic, Nedzad; Szara, Tomasz; Spătaru, Constantin
Background Studying the hyoid bone in dogs is of significant importance in veterinary surgery and anatomy, as it aids in understanding how variations in this structure may affect tongue mobility, swallowing and vocalisation across breeds. Objectives This study aims to provide preliminary insights into the relationship between structural differences in the hyoid bone and breed-specific functional adaptations in tongue shape and movement by analysing shape variations within the hyoid apparatus. Methods Hyoid bones from computed tomography images of 26 dogs were modelled, and principal component analysis (PCA) was conducted to examine shape variation in the hyoid bones. Additionally, the influences of age and weight on hyoid bone shape were assessed. Results PCA showed that PC1 (42.4%) reflected a relatively conservative pattern related to hyoid and skull morphology, whereas PC2 and PC3 indicated greater individual variation. Brachycephalic breeds exhibited a more dorsoventrally positioned and compact hyoid structure, while mesocephalic breeds showed a more aligned and elongated configuration of the stylohyoid and thyrohyoid bones. No significant correlations were found between hyoid shape and age, weight or Procrustes distance, suggesting a stronger influence of genetic factors. Conclusions Understanding the morphological variation of the hyoid bone in dogs contributes to veterinary anatomy and has practical applications in veterinary medicine, particularly in surgical and rehabilitation practices. Given the hyoid apparatus's critical role in swallowing and vocalisation, insights from this study may enhance clinical approaches to treating conditions linked to hyoid bone morphology.
listelement.badge.access-status Open Access ,
Sella Turcica Shape as a Marker for Breed and Sex Classification in Sheep
(MDPI, 2026-03-19) Bektaș Bilgiç, Eylem; Szara, Tomasz; Gündemir, Ozan; Kaska, Zuzanna; Temir, Muhammed Taha; Güzel, Barıș Can; Ișbilir, Fatma; Deveci, Emine Irem; Cherșunaru, Alexandra-Andreea; Spătaru, Mihaela-Claudia
Recent anatomical and morphometric studies indicate that the sella turcica is a structurally informative region and a distinctive anatomical formation that can exhibit shape variation among individuals. The aim of this study was to evaluate, in three dimensions, the extent to which sella turcica morphology differs among three sheep breeds (Akkaraman, Morkaraman, Zom) and between sexes. A total of 102 specimens were examined. All skulls were CT-scanned specifically for this study; the sella turcica region was reconstructed as a three-dimensional model, and 12 anatomical landmarks were manually digitized for each specimen. The findings showed that sella turcica size differed among breeds, with the Zom group exhibiting the largest sella turcica size. In contrast, no clear size difference was observed between females and males. Shape assessment also revealed differences among breeds, largely driven by the separation of Zom from Akkaraman and Morkaraman, whereas no distinct sex-related shape pattern was detected. Importantly, the breed-related shape differences persisted after accounting for size effects. Overall, these results suggest that the sella turcica carries a breed-associated morphological signal in sheep, while showing no pronounced sexual differentiation in the present sample.