RIULS

Repository of Iasi University of Life Sciences, ROMANIA

Welcome to RIULS!

The mission of the University’s institutional repository is to manage, preserve and disseminate, in open access, the academic and institutional output of the university’s academic community. It also aims to promote values and personalities belonging to Romanian agricultural science, by storing digitized versions of rare books and manuscripts from its collections.

The repository is part of the international movement known as open science, which promotes free access to scientific literature. This translates into maximized impact of the work carried out by researchers, contribution to improving access to knowledge, increased visibility of the institution through the works of its authors and improvement of its search engine ranking.

All documents deposited in the repository receive a unique and persistent identifier called a Handle, thus guaranteeing perpetual access to scientific output through permanent links.

RIULS Repository of Iași University of Life Sciences is indexed in Duraspace, OpenDOAR,CORE,Google Scholar,BASE (Bielefeld Academic Search Engine) and ROAR (Registry of Open Access Repositories), global Directories of Open Access Repositories.

Categories in RIULS

Select a category to browse its collections.

Now showing 1 - 3 of 3

Colecții speciale - Ad Gloria Agris / Special Collections-Ad Gloria Agris 141
Cuprinde cărți și publicații periodice rare ale fondatorilor agriculturii și ai învățământului agricol românesc modern, precum și teze de doctorat din domeniul agricol de la început de secol XX.
Publicații ale Bibliotecii - Librum de libris / Publications of the Library - Librum de libris 13
Contains publications created by the Library’s staff: bibliographies, articles, tutorials, etc.
Publicații științifice ale Universității – AgriScriptum / Scientific Publications of the University - AgriScriptum 6543
Contains documents resulting from scientific research produced or edited by the departments, research institutes and study centres of the University: Doctoral Theses, articles published in ISI journals, articles published in the journals edited by the University, patents, scientific projects, etc.

Recent Submissions

listelement.badge.access-status Open Access ,
Immunohistochemical and western blot expression of MMPs, TIMPs, and cytokeratin 10 in feline squamous cell carcinoma
(Frontiers Media, 2026-04-10) Tutu, Paul; Altamura, Gennaro; Bocăneți Daraban, Florentina; Hrițcu, Ozana Maria; Pașca, Aurelian-Sorin; Dascălu, Mihaela Anca; Horodincu, Loredana; Tănase, Oana Irina; Mareș, Mihai; Borzacchiello, Giuseppe
Background: Feline oral and cutaneous squamous cell carcinoma (SCC) are aggressive neoplasms characterized by high local invasiveness. Given its spontaneous occurrence and molecular similarities, feline SCC represents a robust comparative model for human head and neck squamous cell carcinoma (HHNSCC). This pilot study aimed to characterize the expression of metalloproteinases (MMPs), their tissue inhibitors (TIMPs), and cytokeratin 10 (CK10) in relation to Papillomavirus (PV) status, and to explore the viral-molecular relationship in feline oncology. Methods: Ten feline SCC samples (3 oral and 7 cutaneous) were analyzed. PV DNA was detected using PCR with degenerated primers FAP59/FAP64. Protein expression of MMP-2, -9, -13, -14, TIMP-2, -3, and CK10 was analyzed and quantified via immunohistochemistry (IHC) (H-score) and validated through Western blot analysis. Statistical correlations were determined using the Spearman rank correlation coefficient, and statistical differences between groups were assessed via Mann–Whitney U test. Results: PV DNA was identified in 6/10 samples. IHC analysis revealed that MMPs (-2, -9, -13, -14) exhibited stronger cytoplasmic and nuclear immunostaining compared to the more restricted signals of TIMPs and CK10, showing a strong inverse correlation with MMP-2, linking invasiveness to dedifferentiation. Significant positive correlations were found between MMP-9/TIMP-3 and MMP-2/MMP-9. TIMP-2 expression was significantly higher in PV-negative samples. Western blot confirmed these results, showing consistent bands. Conclusion: This pilot study provides the first characterization of MMPs, TIMPs, and CK10 in feline SCC, establishing a foundation for future research into feline PV species and reinforce the value of the feline model in comparative oncology.
listelement.badge.access-status Open Access ,
Acute Toxicity of Three Synthetic Cannabinoids: First In Vivo Preclinical Study
(MDPI, 2026-07-05) Filipiuc, Silviu-Iulian; Tamba, Bogdan-Ionel; Filipiuc, Leontina-Elena; Bild, Veronica; Ababei, Daniela-Carmen; Stanciu, Gabriela-Dumitrița; Gogu, Maria-Raluca; Urîtu, Cristina-Mariana; Solcan, Carmen; Foia, Cezar Ilie; Bil, Walther
Background and Objectives: Synthetic cannabinoids (SCs) are new psychoactive substances associated with acute intoxications. Experimental data obtained under controlled and comparable conditions remain limited for this category of compounds. This descriptive, hypothesis-generating screening study aimed to characterize the acute toxicity profile of three SCs, JWH-007, AM-694, and MAB-CHMINACA. Materials and Methods: Acute toxicity was evaluated in female Swiss Albino mice, in accordance with the OECD 423 guideline, following oral and intraperitoneal administration. Animals were monitored for 14 days for behavioral and clinical signs of toxicity. At the end, histopathological examination was performed to describe organ-level changes. Serum concentrations of the tested compounds were quantified by LC-ESI-MS/MS 24 h after intraperitoneal administration. Results: The three compounds were associated with distinct behavioral, clinical, and histopathological observations. JWH-007 was associated with transient behavioral depression and histopathological changes in peripheral organs. AM-694 was associated with histopathological changes in systemic organs and limited behavioral manifestations. MAB-CHMINACA was associated with acute behavioral toxicity and central nervous system lesions, including neuronal vacuolization, necrosis, oedema, and inflammatory changes. Conclusions: These preliminary findings describe compound-specific in vivo toxicity patterns and may inform the design of future confirmatory studies on SCs’ toxicity. The observed behavioral and histopathological changes should be interpreted as hypothesis-generating and require statistical validation before conclusions can be drawn regarding comparative toxicity, structural class effects, or predictive value for risk stratification.
listelement.badge.access-status Open Access ,
Zinc Potentiates the Renoprotective Effects of SGLT2 Inhibitors in Experimental Diabetes Mellitus in Rats
(MDPI, 2026-05-09) Anton, Irina Claudia; Solcan, Carmen; Mititelu Tarțău, Liliana; Amalinei, Cornelia; Poroch, Mihaela; Poroch, Vladimir; Buca, Beatrice Rozalina; Tarțău, Cosmin-Gabriel; Pelin, Ana-Maria; Botnariu, Gina Eosefina
background: Diabetic kidney disease is a common and serious complication of type 2 diabetes mellitus (T2DM) and represents a major contributor to chronic kidney disease (CKD) globally. While sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated significant renoprotective effects, the potential advantages of combining these agents with micronutrients such as zinc (Zn), known for its antioxidant, anti-inflammatory, and metabolic regulatory properties, have not been fully investigated. This study aimed to assess the effects of dapagliflozin (DAPA) and empagliflozin (EMPA), administered either alone or alongside Zn, in an experimental diabetes model. Methods: T2DM was induced in Sprague-Dawley rats through a high-fat diet (HFD) followed by a low dose of streptozotocin (STZ). Seven experimental groups were established: a control group, an untreated diabetic group, and treatment groups receiving DAPA, EMPA, or their combinations with Zn. Metabolic parameters, renal function, and histopathological alterations were assessed, while immunohistochemistry was used to evaluate the expression of inflammatory and fibrotic markers. Results: Diabetic rats exhibited sustained hyperglycemia, metabolic imbalance, and significant renal damage, accompanied by elevated levels of inflammatory and fibrotic markers. Treatment with SGLT2 inhibitors improved metabolic status, mitigated kidney injury, and reduced inflammatory marker expression. Zn association further potentiated these effects, with the most pronounced benefits observed when combined with EMPA. Conclusions: These findings suggest that SGLT2 inhibitors exert strong renoprotective effects in experimental diabetic nephropathy. Zn supplementation may amplify these benefits through its antioxidant and anti-inflammatory actions. The combination of EMPA and Zn demonstrated the greatest protective effect, highlighting the potential of multi-target therapeutic strategies in diabetic kidney disease.
listelement.badge.access-status Open Access ,
Cationic curdlan-based hydrogels loaded with Calendula officinalis-decorated silver nanoparticles: Synthesis, characterization and in vitro biological properties
(Elsevier, 2026-07-06) Suflet, Dana M.; Popescu, Irina; Luca, Andreea; Butnaru, Maria; Rîmbu, Cristina-Mihaela; Horhogea, Cristina-Elena; Constantin, Marieta
Curdlan, known for its biomedical applications, and a quaternary derivative thereof with antimicrobial properties were used to prepare new hydrogels for potential applications in wound dressings. To enhance the antimicrobial and antioxidant properties, silver nanoparticles synthesised in the presence of Calendula officinalis, known for its wound healing activity, were entrapped in the hydrogels. The parameters of the green synthesis of metallic nanoparticles were studied to determine the optimal conditions. Then, the spherical nanoparticles (22 nm) containing biologically active compounds from the plant extract were introduced into the cross-linking process of curdlan and quaternary derivative. The hydrogels exhibited a well-defined porous morphology (60–70 μm) with interconnected pores, which can retain up to 20.34 g/g fluid under skin-simulated conditions. The new hydrogels, with an elastic modulus between 4.85 and 11.31 kPa, exhibit complete and rapid shape recovery after progressive compression of at least five cycles. In addition, they have been shown to be biocompatible in contact with human dermal fibroblasts and can even induce their migration and proliferation within the first 8 h of contact. They have antioxidant properties and antimicrobial activity against S. aureus and E. coli, and the entrapment of silver nanoparticles leads to the augmentation of these properties.
listelement.badge.access-status Open Access ,
Haematological response of Acipenser stellatus juveniles in cold shock stress
(“Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine, Iaşi, 2019) Grecu, Iulia; Docan, Angelica; Dediu, Lorena; Antache, Alina; Crețu, Mirela; Maereanu, Marilena
During the intensive growth of the sturgeons, different stressful factors may occur which could act isolated or in association, influencing their physiological state. In these conditions, the organism tries to cope through a series of biochemical and physiological changes as a result of the activation, in cascade, of some mechanisms of the neuroendocrine response to these stressors. This paper presents the results of the haematological investigations in a controlled experiment that followed the effect of the cold shock stress of water temperature, in the range 12.8 oC ÷ 7 oC (initially, after 1 hour, respectively after 3 hours) on the physiology of the Acipenser stellatus species (stellate sturgeon), a very valuable species for sturgeon farming in Romania. This experiment was part of a series of experiments applied to intensive sturgeon breeding with the aim of selecting specific molecular and biochemical markers (gene and protein expressions) to allow the analysis of the response mechanisms to stress factors in aquaculture. Haematological indices and erythrocyte constants were determined using standard methods for veterinary haematology and the data obtained were statistically processed. The determined values of the haematological parameters ranged near the lower limit of the optimum interval for Acipenseridae. In the context of our study, although there was a constant increasing tendency of haematocrit (Ht) values with the raise of the exposure to cold (14.46% - initially, 16.39% - after 1 hour, respectively 17.51% - after 3 hours), in parallel with a less uniform reaction of the other haematological parameters, the statistical analysis did not reveal significant differences between the three experimental groups. The obtained data show the evolution of the haematological profile of the stellate sturgeon and it is useful in completing the database with reference values for research in the field of sturgeon culture