RIULS

Repository of Iasi University of Life Sciences, ROMANIA

Welcome to RIULS!

The mission of the University’s institutional repository is to manage, preserve and disseminate, in open access, the academic and institutional output of the university’s academic community. It also aims to promote values and personalities belonging to Romanian agricultural science, by storing digitized versions of rare books and manuscripts from its collections.

The repository is part of the international movement known as open science, which promotes free access to scientific literature. This translates into maximized impact of the work carried out by researchers, contribution to improving access to knowledge, increased visibility of the institution through the works of its authors and improvement of its search engine ranking.

All documents deposited in the repository receive a unique and persistent identifier called a Handle, thus guaranteeing perpetual access to scientific output through permanent links.

RIULS Repository of Iași University of Life Sciences is indexed in Duraspace, OpenDOAR,CORE,Google Scholar,BASE (Bielefeld Academic Search Engine) and ROAR (Registry of Open Access Repositories), global Directories of Open Access Repositories.

Categories in RIULS

Select a category to browse its collections.

Now showing 1 - 3 of 3

Colecții speciale - Ad Gloria Agris / Special Collections-Ad Gloria Agris 141
Cuprinde cărți și publicații periodice rare ale fondatorilor agriculturii și ai învățământului agricol românesc modern, precum și teze de doctorat din domeniul agricol de la început de secol XX.
Publicații ale Bibliotecii - Librum de libris / Publications of the Library - Librum de libris 13
Contains publications created by the Library’s staff: bibliographies, articles, tutorials, etc.
Publicații științifice ale Universității – AgriScriptum / Scientific Publications of the University - AgriScriptum 6503
Contains documents resulting from scientific research produced or edited by the departments, research institutes and study centres of the University: Doctoral Theses, articles published in ISI journals, articles published in the journals edited by the University, patents, scientific projects, etc.

Recent Submissions

listelement.badge.access-status Open Access ,
Biocompatible and Antimicrobial Cellulosic Support via Bioactive Emulsion-Based Film
(MDPI, 2026-04-28) Danila, Angela; Chirilă, Laura; Popescu, Carmen-Mihaela; Voinea, Ionela Cristina; Rîmbu, Cristina-Mihaela; Türkoglu, Gizem Ceylan; Mureșan, Emil-Ioan; Costea, Mariana
Due to biodegradability, functionalization, and sustained release, polymer-based films are widely used in different industries. This study explores a bioactive emulsion-based film obtained using high-methoxy pectin (HMP), Origanum onites L. essential oil, and a hydroalcoholic extract of Thymus vulgaris L., prepared using various emulsion recipes. The emulsions obtained were applied to cellulose supports intended for topical applications. Bioactive textiles were analyzed using SEM-EDS elemental mapping, ATR FT-IR spectroscopy, biocompatibility assessment, antimicrobial activity assays, and analysis of comfort indices. SEM images of textile supports treated with bioactive emulsions confirmed the creation of a film surface and that the homogeneity of the film increases with increasing amount of glycerin, which acts as a plasticizer. Infrared spectra combined with their second derivatives and PCA indicate the presence of oregano essential oil, thyme extract, and pectin on the surface of the cotton. The biocompatibility evaluation of functionalized cotton supports revealed minimal cytotoxic effects on HaCaT human keratinocytes after 24 h of exposure. The results of the analyses showed that bioactive textile supports also exhibit antimicrobial activity. Therefore, the active emulsions with pectin, oregano essential oil, and hydroalcoholic extract of thyme provide biocompatible and antimicrobial active films by applying on cellulosic supports.
listelement.badge.access-status Open Access ,
Azole–Flavonoid Hybrids as Emerging Anticancer Agents: A Bioactivity-Focused Review
(MDPI, 2026-02-20) Lipovanu, Mihaela; Miron, Anca; Filip, Nina; Horhogea, Cristina-Elena; Aprotosoaie, Ana Clara
Despite notable progress in drug discovery, cancer treatment remains hindered by limited therapeutic efficacy, poor target specificity, adverse effects, and the development of drug resistance. Molecular hybridization, which integrates two or more bioactive entities into a single molecule, has shown considerable potential to overcome these limitations. Since both azoles and flavonoids have demonstrated anticancer potential, extensive studies have been undertaken to combine the two entities and enhance the bioactivity of the resulting hybrids. In this context, numerous azole–flavonoid hybrids have been synthesized and investigated for their anticancer potential. This review provides an overview of the azole–flavonoid hybrids that are promising candidates for novel anticancer drug development, highlighting their superior antitumor potency compared to reference drugs, multitarget activity, tumor-selective cytotoxicity, efficacy against drug-resistant tumor cells, and structure–activity relationships. The review covers 250 hybrids, primarily triazole–chalcone hybrids but also triazole–flavone, flavanone, flavonol, and isoflavone hybrids, as well as other azole–flavonoid hybrids (imidazole–, pyrazole–, isoxazole–, and thiazole–flavonoid hybrids).
listelement.badge.access-status Open Access ,
The Role of Spacer Segments in Increasing the Transfection Efficacy of Au-Core Polymeric-Shell Nanoparticulate Gene Vectors
(American Chemical Society, 2026-01-14) Bostiog, Denisse I.; Năstasă, Valentin; Cristina M. Al-Matarneh; Peptanariu, Dragoș; Mareș, Mihai; Pașca, Sorin-Aurelian; Bostănaru-Iliescu, Andra-Cristina; Crăciun, Bogdan F.; Vasiliu, Tudor; Puf, Răzvan; Maier, Stelian S.; Pinteală, Mariana
The surface chemistry of gold nanoparticles is a key determinant of their final biological properties. In this study, we investigated the influence of the PEG chain length, positioned between the gold core and the cationic polymer, on the transfection efficiency in HeLa and HGF cell lines. Two types of nonviral vectors were synthesized from the same AuNPs, which were subsequently functionalized with PEG of 1000 and 2500 Da, respectively. Onto these PEG chains, identical copolymeric sequences of PEI2000-PEG500-GA were covalently attached to provide quasi-shielding (via PEG500) and enable tumor targeting/accumulation (via GA). Both vectors demonstrated that such functionalization enhances cellular uptake and targeting specificity while exhibiting excellent DNA delivery efficiency, minimal in vitro cytotoxicity, and no detectable in vivo adverse effects following intravenous administration in animal models. A superior loading capacity was observed when the PEG linked to the gold core was 2500 Da, suggesting a contribution from solvation-driven interactions.
listelement.badge.access-status Open Access ,
Co-encapsulated fluorescent magnetic nanoparticles for potential applications in breast cancer therapy: Exploratory in vitro and in vivo studies
(Elsevier, 2026-04-26) Sandu, Ștefan; Dodi, Gianina; Gardikiotis, Ioannis; Crețu, Bianca-Elena-Beatrice; Luca, Andreea; Cojocaru, Florina Daniela; Vereștiuc, Liliana; Pașca, Sorin-Aurelian; Balan, Vera
This study describes, for the first time in the literature, a suitable approach to develop co-encapsulated magnetic nanoparticles based on fluorescent biotinylated N-palmitoyl chitosan, hydrophobic magnetite, Docetaxel and Verapamil. The multicomponent nanostructures were obtained using a two-step method: ultrasonication-induced self-assembly followed by ionic gelation. Structural composition was confirmed by infrared spectroscopy; the magnetic nanostructures displayed an average hydrodynamic diameter of 322.20 ± 2.50 nm, a positive surface charge (5.63 ± 0.16 mV), good magnetic saturation (13.35 emu/g) and superparamagnetic behavior. In vitro drug release studies revealed a pH-responsive behavior for both encapsulated agents, with an enhanced release of the Verapamil. Cytotoxicity evaluation using live/dead assays on MCF-7 tumor spheroids embedded in collagen-based hydrogels demonstrated a substantial therapeutic effect. Serum interleukin-8 (IL-8) levels were quantified to evaluate systemic inflammatory responses following intravenous administration of drug free magnetic nanoparticles. IL-8 concentrations were considerably increased at day 3, indicating an acute inflammatory response, decreased during the subacute phase (days 7 and 14) and returned to control levels by day 21, demonstrating good biocompatibility. No significant toxicity was observed for magnetic nanoparticles in the rats. Overall, these findings suggest that the developed magnetic nanoplatforms represents a promising candidate for breast cancer applications and merits further in vivo investigation to elucidate the action mechanism of encapsulated therapeutics and their pharmacologic activity.
listelement.badge.access-status Open Access ,
MRI-Based Radiomics Reveals Cannabinoid-Associated Tumor Phenotypes in a Murine Breast Cancer Model
(MDPI, 2026-03-31) Creangă-Murariu, Ioana; Pricope, Cosmin-Vasilică; Ciorpac, Mitică; Anaby, Debbie; Cohen, Kfir; Urîtu, Cristina-Mariana; Szilagyi, Andrei; Gogu, Raluca-Maria; Jalloul, Wael; Aniță, Adriana-Elena; Anită, Dragoș-Constantin; Baisan, Radu-Andrei; Alexa-Stratulat, Teodora; Tamba, Bogdan-Ionel
Introduction and Aim: Assessment of antitumor activity in preclinical models remains challenging when relying solely on conventional size-based imaging, particularly for complex agents such as cannabinoids, whose biological effects may not translate into early volumetric tumor changes. Cannabinoid formulations, including the synthetic cannabinoid JWH-182, Cannabixir® Medium dried flowers, and Cannabixir® THC full extract, exhibit diverse and potentially subtle effects on tumor biology. Radiomics enables high-throughput extraction of quantitative imaging features that capture intratumoral heterogeneity beyond gross tumor volume. The primary aim of this study was to evaluate the utility of MRI-based radiomics as a sensitive tool for detecting cannabinoid-associated tumor phenotypic modulation in a preclinical breast cancer model. Methods: Orthotopic breast tumors were induced in mice using the 4T1 cell line. Animals received cannabinoid formulations in combination with chemotherapy according to a predefined protocol. Tumor burden was assessed at baseline and post-treatment using ultrasonography and whole-body MRI to calculate tumor doubling time. T1- and T2-weighted MRI datasets were segmented and analyzed using radiomics to extract morphometric and signal-based features. Results: Conventional imaging revealed no significant differences in tumor doubling time between most cannabinoid-treated groups and controls, except for accelerated growth in animals treated with Cannabixir® THC full extract. In contrast, radiomics identified distinct, compound-specific tumor phenotypes, including structural features consistent with reduced aggressiveness, in JWH-182-treated tumors, despite similar volumetric growth patterns. Conclusion: MRI-based radiomics sensitively captures cannabinoid-associated tumor phenotype alterations beyond volumetric assessment, supporting its value as a pharmaco-imaging tool for characterizing treatment-related tumor biology in preclinical oncology.