RIULS

Repository of Iasi University of Life Sciences, ROMANIA

Welcome to RIULS!

The mission of the University’s institutional repository is to manage, preserve and disseminate, in open access, the academic and institutional output of the university’s academic community. It also aims to promote values and personalities belonging to Romanian agricultural science, by storing digitized versions of rare books and manuscripts from its collections.

The repository is part of the international movement known as open science, which promotes free access to scientific literature. This translates into maximized impact of the work carried out by researchers, contribution to improving access to knowledge, increased visibility of the institution through the works of its authors and improvement of its search engine ranking.

All documents deposited in the repository receive a unique and persistent identifier called a Handle, thus guaranteeing perpetual access to scientific output through permanent links.

RIULS Repository of Iași University of Life Sciences is indexed in Duraspace, OpenDOAR,CORE,Google Scholar,BASE (Bielefeld Academic Search Engine) and ROAR (Registry of Open Access Repositories), global Directories of Open Access Repositories.

Categories in RIULS

Select a category to browse its collections.

Now showing 1 - 3 of 3

Colecții speciale - Ad Gloria Agris / Special Collections-Ad Gloria Agris 141
Cuprinde cărți și publicații periodice rare ale fondatorilor agriculturii și ai învățământului agricol românesc modern, precum și teze de doctorat din domeniul agricol de la început de secol XX.
Publicații ale Bibliotecii - Librum de libris / Publications of the Library - Librum de libris 13
Contains publications created by the Library’s staff: bibliographies, articles, tutorials, etc.
Publicații științifice ale Universității – AgriScriptum / Scientific Publications of the University - AgriScriptum 6541
Contains documents resulting from scientific research produced or edited by the departments, research institutes and study centres of the University: Doctoral Theses, articles published in ISI journals, articles published in the journals edited by the University, patents, scientific projects, etc.

Recent Submissions

listelement.badge.access-status Open Access ,
Zinc Potentiates the Renoprotective Effects of SGLT2 Inhibitors in Experimental Diabetes Mellitus in Rats
(MDPI, 2026-05-09) Anton, Irina Claudia; Solcan, Carmen; Mititelu Tarțău, Liliana; Amalinei, Cornelia; Poroch, Mihaela; Poroch, Vladimir; Buca, Beatrice Rozalina; Tarțău, Cosmin-Gabriel; Pelin, Ana-Maria; Botnariu, Gina Eosefina
background: Diabetic kidney disease is a common and serious complication of type 2 diabetes mellitus (T2DM) and represents a major contributor to chronic kidney disease (CKD) globally. While sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated significant renoprotective effects, the potential advantages of combining these agents with micronutrients such as zinc (Zn), known for its antioxidant, anti-inflammatory, and metabolic regulatory properties, have not been fully investigated. This study aimed to assess the effects of dapagliflozin (DAPA) and empagliflozin (EMPA), administered either alone or alongside Zn, in an experimental diabetes model. Methods: T2DM was induced in Sprague-Dawley rats through a high-fat diet (HFD) followed by a low dose of streptozotocin (STZ). Seven experimental groups were established: a control group, an untreated diabetic group, and treatment groups receiving DAPA, EMPA, or their combinations with Zn. Metabolic parameters, renal function, and histopathological alterations were assessed, while immunohistochemistry was used to evaluate the expression of inflammatory and fibrotic markers. Results: Diabetic rats exhibited sustained hyperglycemia, metabolic imbalance, and significant renal damage, accompanied by elevated levels of inflammatory and fibrotic markers. Treatment with SGLT2 inhibitors improved metabolic status, mitigated kidney injury, and reduced inflammatory marker expression. Zn association further potentiated these effects, with the most pronounced benefits observed when combined with EMPA. Conclusions: These findings suggest that SGLT2 inhibitors exert strong renoprotective effects in experimental diabetic nephropathy. Zn supplementation may amplify these benefits through its antioxidant and anti-inflammatory actions. The combination of EMPA and Zn demonstrated the greatest protective effect, highlighting the potential of multi-target therapeutic strategies in diabetic kidney disease.
listelement.badge.access-status Open Access ,
Cationic curdlan-based hydrogels loaded with Calendula officinalis-decorated silver nanoparticles: Synthesis, characterization and in vitro biological properties
(Elsevier, 2026-07-06) Suflet, Dana M.; Popescu, Irina; Luca, Andreea; Butnaru, Maria; Rîmbu, Cristina-Mihaela; Horhogea, Cristina-Elena; Constantin, Marieta
Curdlan, known for its biomedical applications, and a quaternary derivative thereof with antimicrobial properties were used to prepare new hydrogels for potential applications in wound dressings. To enhance the antimicrobial and antioxidant properties, silver nanoparticles synthesised in the presence of Calendula officinalis, known for its wound healing activity, were entrapped in the hydrogels. The parameters of the green synthesis of metallic nanoparticles were studied to determine the optimal conditions. Then, the spherical nanoparticles (22 nm) containing biologically active compounds from the plant extract were introduced into the cross-linking process of curdlan and quaternary derivative. The hydrogels exhibited a well-defined porous morphology (60–70 μm) with interconnected pores, which can retain up to 20.34 g/g fluid under skin-simulated conditions. The new hydrogels, with an elastic modulus between 4.85 and 11.31 kPa, exhibit complete and rapid shape recovery after progressive compression of at least five cycles. In addition, they have been shown to be biocompatible in contact with human dermal fibroblasts and can even induce their migration and proliferation within the first 8 h of contact. They have antioxidant properties and antimicrobial activity against S. aureus and E. coli, and the entrapment of silver nanoparticles leads to the augmentation of these properties.
listelement.badge.access-status Open Access ,
Haematological response of Acipenser stellatus juveniles in cold shock stress
(“Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine, Iaşi, 2019) Grecu, Iulia; Docan, Angelica; Dediu, Lorena; Antache, Alina; Crețu, Mirela; Maereanu, Marilena
During the intensive growth of the sturgeons, different stressful factors may occur which could act isolated or in association, influencing their physiological state. In these conditions, the organism tries to cope through a series of biochemical and physiological changes as a result of the activation, in cascade, of some mechanisms of the neuroendocrine response to these stressors. This paper presents the results of the haematological investigations in a controlled experiment that followed the effect of the cold shock stress of water temperature, in the range 12.8 oC ÷ 7 oC (initially, after 1 hour, respectively after 3 hours) on the physiology of the Acipenser stellatus species (stellate sturgeon), a very valuable species for sturgeon farming in Romania. This experiment was part of a series of experiments applied to intensive sturgeon breeding with the aim of selecting specific molecular and biochemical markers (gene and protein expressions) to allow the analysis of the response mechanisms to stress factors in aquaculture. Haematological indices and erythrocyte constants were determined using standard methods for veterinary haematology and the data obtained were statistically processed. The determined values of the haematological parameters ranged near the lower limit of the optimum interval for Acipenseridae. In the context of our study, although there was a constant increasing tendency of haematocrit (Ht) values with the raise of the exposure to cold (14.46% - initially, 16.39% - after 1 hour, respectively 17.51% - after 3 hours), in parallel with a less uniform reaction of the other haematological parameters, the statistical analysis did not reveal significant differences between the three experimental groups. The obtained data show the evolution of the haematological profile of the stellate sturgeon and it is useful in completing the database with reference values for research in the field of sturgeon culture
listelement.badge.access-status Open Access ,
The effect of Saccharomyces boulardii yeast feed supplementation on growth parameters and biochemical composition of carp (Cyprinus carpio)
(“Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine, Iaşi, 2019) Savin, Viorica; Patriche, N.; Mocanu, Elena; Tenciu, Magdalena; Lăcătuș, Marilena; Popa, D.; Savin, C.
The aim of this study is to evaluate the effect of the yeast Sacharomices Boulardii (SB), on the growth performance, the health and the survival rate of the carp (Cyprinus carpio) grown in recirculating system, by analyzing the biotechnological and biochemical indicators. The experiment was performed over a period of 30 days. The biological material used in this experiment was carp (Cyprinus carpio). A number of 150 fish, with an average body weight of approximately 100 grams, were equally distributed in 2 experimental tank and 1 control tank in the recirculating system. The yeast was supplemented with food, in a classic feed with a content of 32% protein, according to the specialized literature (SC Aquasarb, 1998)[15], in percentage of 0.75% in B1, respectively 2.5 % in B2. In the control tank, B0, a classic feed was administered, without the addition of yeast. The growth parameters and the biochemical composition were determined at the beginning and the end of the experiment. The results showed that there are not very big differences regarding the individual weight growth between the 3 tank; however, the highest weight gain (33.95 g) was obtained in B2 compared to the lowest (33.51 g) obtained in the control tank, B0. The results also showed that at the end of the experiment the survival rate in B1 and B2 was 100%, compared to 96% in the control basin B0. A better food conversion rate, FCR, was obtained in B2 (1.20), compared to 1.30 in B1, respectively 1.45 in B0. The highest protein content in the fish carcass was present in B2 (18.01%), compared to 17.01 in B0, respectively 17.60 in B1. The conclusion is that supplementation of the carp feed grown in the recirculating system with probiotics from yeast Sacharomices boulardii has positive results on the growth performance, the health and the survival rate of the carp, the best results being obtained with a supplement of 2.5% probiotics.
listelement.badge.access-status Open Access ,
Bioactive-Enriched Chitosan/Poly(vinyl Alcohol) Electrospun Nanofibers for Wound Healing: In Vitro and In Vivo Evaluation
(MDPI, 2026-04-05) Iurașcu, Teodora; Iacob, Andreea-Teodora; Solcan, Carmen; Urîtu, Cristina-Mariana; Profire, Bianca-Ștefania; Marangoci, Narcisa Laura; Coroaba, Adina; Andrei Szilagyi; Costăchescu, Ivona; Gogu, Maria-Raluca; Filipiuc, Leontina-Elena; Profire, Lenuța
Background: Wound healing remains a major clinical challenge, often impaired by persistent inflammation, oxidative stress, and abnormal extracellular matrix remodeling. Electrospun nanofibers (NFs) have emerged as promising wound dressing platforms due to their biomimetic structure and capacity to incorporate multiple bioactive compounds (ACs) with synergistic therapeutic effects. Objectives: This study aimed to biologically assess novel chitosan/poly(vinyl alcohol) (CH/PVA) NFs functionalized with natural active compounds (L-arginine—ARG, allantoin—ALA, royal jelly—RJ, and curcumin—CUR) as multifunctional systems for wound healing and tissue remodeling. Methods: The nanofibrous systems performed the in vitro evaluation of antioxidant activity (DPPH, ABTS, FRAP, PRAP), anti-inflammatory potential (protein denaturation test), hemocompatibility, and cytocompatibility using dermal fibroblasts. In vivo healing performance was evaluated in an excisional wound model using macroscopic wound contraction analysis, histopathology, and immunohistochemical staining (MMP-9, CD31, VEGF-A, α-SMA). Results: The bioactive-enriched CH/PVA NFs exhibited strong antioxidant and anti-inflammatory activity, excellent hemocompatibility (hemolysis < 5%), and excellent cytocompatibility, with promoting fibroblast proliferation. In vivo experiments revealed that the treated groups exhibited accelerated wound closure, improved re-epithelialization, increased angiogenesis, and showed more efficient tissue remodeling compared to the controls, as validated by histological and immunohistochemical studies. Conclusions: The findings indicate that bioactive-enriched CH/PVA NFs serve as effective, biocompatible, and multifunctional matrices for wound healing, hence endorsing their potential for further translational advancement in skin regeneration applications.