Miron, Liviu-DanMareș, MihaiNăstasă, ValentinSpulber, MarianaFifere, AdrianPinteală, MarianaHarabagiu, ValeriaSimionescu, Bogdan C.2025-02-242025-02-242008-10-03Miron, Liviu, M. Mareș, V. Năstasă, Mariana Spulber, A. Fifere, Mariana Pinteală, Valeria Harabagiu, B. C. Simionescu. 2009. “Water soluble sulconazole-b-cyclodextrin complex: physico-chemical characterization and preliminary pharmacological studies”. Journal of Inclusion Phenomena and Macrocyclic Chemistry 63 (1): 159-162. DOI: 10.1007/s10847-008-9501-x0923-0750https://link.springer.com/article/10.1007/s10847-008-9501-xhttps://repository.iuls.ro/handle/20.500.12811/5160Sulconazole-b-cyclodextrin water soluble inclusion complex was prepared by freeze drying method in distilled water. The formation of inclusion complex between b-cyclodextrin and sulconazole has been studied in a previous work. Preliminary pharmacological studies concerning the antifungal activity showed that the minimal inhibitory concentrations for 90% of the tested strains decreased. Also, the acute toxicity of the sulconazole-bcyclodextrin complex is smaller comparing with the pure drug, analyzed alone. These results recommend the described conjugates as future promising therapeutic agents.enAttribution 4.0 International (CC BY 4.0)http://creativecommons.org/licenses/by/4.0Sulconazole nitrateCyclodextrinAntifungal activityAcute toxicityphysico-chemical characterizationpharmacological studiesArticle1573-111110.1007/s10847-008-9501-x