Spulber, MarianaMiron, Liviu-DanMareș, MihaiNăstasă, ValentinPinteală, MarianaFifere, AdrianHarabagiu, ValeriaSimionescu, Bogdan C.2025-02-212025-02-212009-05-30Spulber, Mariana, L. Miron, M. Mareș, V. Năstasă, Mariana Pinteală, A. Fifere, Valeria Harabagiu, B. C. Simionescu. 2009. “Water soluble 5 FC complexes, preliminary pharmacological studies”. Journal of Inclusion Phenomena and Macrocyclic Chemistry 65 (3): 431-435. DOI: 10.1007/s10847-009-9594-x0923-0750https://link.springer.com/article/10.1007/s10847-009-9594-xhttps://repository.iuls.ro/handle/20.500.12811/5159Flucytosine-b-cyclodextrin and hydroxypropyl b-cyclodextrin water soluble inclusion complex were prepared by freeze drying method in distilled water. The formation of inclusion complex between b-cyclodextrins and flucytosine has been studied and fully described in our previous work [1]. In this paper we are describing the results obtained concerning the antifungal activity of this new compounds. As expected the new inclusion complexes presents a semnificative increase of the antifungal activity, illustrated by the reduction of the minimal inhibitory concentrations for 50 and 90% of the tested strains decreased. Also, the acute toxicity of the flucytosine b cyclodextrin and hydroxypropyl b cyclodextrin complex is smaller comparing with the pure drug, analyzed alone. These results recommend the described conjugates as future promising therapeutic agents.enAttribution 4.0 International (CC BY 4.0)http://creativecommons.org/licenses/by/4.0FlucytosineAntifungal activityMIC 50MIC 90Article1573-111110.1007/s10847-009-9594-x