The spectrophotometric analysis method of metamizole from pharmaceutical tablets: investigation of linearity, limit of detection and limit of quantification

Abstract

The aim of this research was to exactly quantify the pure sodium metamizole content frompharmaceutical tablets, by using a spectro-photometric analysis method in visible range. The method applied has been subjected to a validation protocol which consisted in analyzing the following parameters: linearity of the method, limit of detection (LD) and limit of quantification (LQ). The pure sodium metamizole amount in a pharmaceutical tablet was found to be 477.477 mg, assigned to a percentage content of 95.495 %, close to official declared amount (500 mg), presentingan average percentage deviation of 4.505 % from the officiallystatedactive substance content. This value was situated below the maximum admissible percentage deviation of active substance content (± 5%), stated by Romanian Pharmacopeia, X-thEdition.