2009

Permanent URI for this collectionhttps://repository.iuls.ro/handle/20.500.12811/5157

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    Water soluble sulconazole-b-cyclodextrin complex: physico-chemical characterization and preliminary pharmacological studies
    (Springer Science+Business Media B.V., 2008-10-03) Miron, Liviu-Dan; Mareș, Mihai; Năstasă, Valentin; Spulber, Mariana; Fifere, Adrian; Pinteală, Mariana; Harabagiu, Valeria; Simionescu, Bogdan C.
    Sulconazole-b-cyclodextrin water soluble inclusion complex was prepared by freeze drying method in distilled water. The formation of inclusion complex between b-cyclodextrin and sulconazole has been studied in a previous work. Preliminary pharmacological studies concerning the antifungal activity showed that the minimal inhibitory concentrations for 90% of the tested strains decreased. Also, the acute toxicity of the sulconazole-bcyclodextrin complex is smaller comparing with the pure drug, analyzed alone. These results recommend the described conjugates as future promising therapeutic agents.
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    Water soluble 5 FC complexes, preliminary pharmacological studies
    (Springer Science+Business Media B.V, 2009-05-30) Spulber, Mariana; Miron, Liviu-Dan; Mareș, Mihai; Năstasă, Valentin; Pinteală, Mariana; Fifere, Adrian; Harabagiu, Valeria; Simionescu, Bogdan C.
    Flucytosine-b-cyclodextrin and hydroxypropyl b-cyclodextrin water soluble inclusion complex were prepared by freeze drying method in distilled water. The formation of inclusion complex between b-cyclodextrins and flucytosine has been studied and fully described in our previous work [1]. In this paper we are describing the results obtained concerning the antifungal activity of this new compounds. As expected the new inclusion complexes presents a semnificative increase of the antifungal activity, illustrated by the reduction of the minimal inhibitory concentrations for 50 and 90% of the tested strains decreased. Also, the acute toxicity of the flucytosine b cyclodextrin and hydroxypropyl b cyclodextrin complex is smaller comparing with the pure drug, analyzed alone. These results recommend the described conjugates as future promising therapeutic agents.